Is the reversal of cellular aging Dr. Dean Ornish demonstrated with lifestyle changes due to the plant-based diet, the exercise or just to the associated weight loss?
D H Ryan, M A Espeland, G D Foster, S M Haffner, V S Hubbard,
K C Johnson, S E Kahn, W C Knowler, S Z Yanovski; Look
AHEAD Research Group. 2003. Look AHEAD (Action for Health
in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2
diabetes. Control Clin Trials. Oct;24(5):610-28.
K Steczkiewicz, M T Zimmermann, M Kurcinski, B A Lewis, D
Dobbs, A Kloczkowski, R L Jernigan, A Kolinski, K Ginalski.
2011. Human telomerase model shows the role of the TEN
domain in advancing the double helix for the next
polymerization step. Proc Natl Acad Sci U S A. Jun
D Ornish, J Lin, J Daubenmier, G Weidner, E Epel, C Kemp, M J M
Magbanua, R Marlin, L Yglecias, P R Carroll, E H Blackburn.
Increased telomerase activity and comprehensive lifestyle
changes: a pilot study. Lancet Oncol. 2008 Nov;9(11):1048-57.
E Skordalakes. Telomerase and the benefits of healthy living.
Lancet Oncol. 2008 Nov;9(11):1023-4.
E S Epel, E H Blackburn, J Lin, F S Dhabhar, N E Adler, J D
Morrow, R M Cawthon. Accelerated telomere shortening in
response to life stress. Proc Natl Acad Sci U S A. 2004 Dec
E H Blackburn, E S Epel. Telomeres and adversity: Too toxic to
ignore. Nature. 2012 Oct 11;490(7419):169-71.
A K Damjanovic, Y Yang, R Glaser, J K Kiecolt-Glaser, H Nguyen, B
Laskowski, Y Zou, D Q Beversdorf, N Weng. Accelerated
telomere erosion is associated with declining immune
function of caregivers of alzheimer’s disease patients. J
Immunol. 2007 Sep 15;179(6):4249-54.
K Ahola, I Siren, M Kivimaki, S Ripatti, A Aromaa, J Lonnqvist,
I Hovatta. Work-Related Exhaustion and Telomere Length:
A populated-based study. PLoS One. 2012;7(7):e40186.
I Shalev, T E Moffitt, K Sugden, B Williams, R M Houts, A Danese,
J Mill, L Arsenaeult, A Caspi. Exposure to violence during
childhood is associated with telomere erosion from 5-10 years
of age: a longitudinal study. Mol Psychiatry. 2013
T L Jacobs, E S Epel, J Lin, E H lackburn, O M Wolkowitz,
D A Bridwell, A P Zanesco, S R Aichele, B K Sahdra, K A
Maclean, B G King, P R Shaver, E L Rosenberg, E Ferrer,
B A Wallace, C D Saron. Intensive meditation training,
immune cell telomerase activity, and psychological
mediators. Psychoneuroendocrinology. 2011 Jun;36(5):664-81.
E A Hoge, M M Chen, E Orr, C A Metcalf, L E Fischer, M H Pollack,
I DeVivo, N M Simon. Loving-Kindness meditation practice
associated with longer telomeres in women. Brain Behav
Immun. 2013 Aug;32:159-63.
H Lavretsky, E S Epel, P Siddarth, N Nazarian, N S Cyr, D S Khalsa,
J Lin, E Blackburn, M R Irwin. A pilot study of yogic
meditation for family dementia caregivers with depressive
symptoms: effects on mental health, cognition and
telomerase activity. Int J Geriatr Psychiatry. 2013
C Werner, T Furster, T Widmann, J Poss, C Roggia, M Hanhoun,
J Scharhag, N Buchner, T Meyer, W Kindermann, J Haendeler,
M Bohm, U Laufs. Physical exercise prevents cellular
senescence in circulating leukocytes in the vessel wall.
Circulation. 2009 Dec 15;120(24):2438-47.
L F Cherkas, J L Hunkin, B S Kato, B Richards, J P Gardner,
G L Surdulescu, M Kimura, X Lu, T D Spector, A Aviv. The
association between physical activity in leisure time and
leukocyte telomere length. Arch Intern Med. 2008 Jan
J Kim, J Ko, D Lee, I Lim, H Bang. Habitual physical exercise has
beneficial effects on telomere length in postmenopausal
women. Menopause. 2012 Oct;19(10):1109-15.
C Mason, R Risques, L Xiao, C R Duggan, I Imayama, K L Campbell,
A Kong, K E Foster-Schubert, C Y Wang, C M Alfano,
G L Blackburn, P S Rabinovitch, A McTiernan. Independent
and combined effects of dietary weight loss and exercise on
leukoctye telomere length in postmenopausal women. Obesity
(Silver Spring). 2013 Dec;21(12):E549-54.
F Marcon, E Siniscalchi, R Crebelli, C Saieva, F Sera, P Fortini,
V Simonelli, D Palli. Diet-related telomere shortening and
chromosome stability. Mutagenesis. 2012 Jan;27(1):49-57.
A Tianen, S Mannisto, P A Blomstedt, E Moltchanova, M-M Perala,
N E Kaartinen, E Kajantie, L Kananen, I Hovatta, J G Eriksson.
Leukocyte telomere length and its relation to food and
nutrient intake in an elderly population. Eur J Clin Nutr.
I Shalev, S Entringer, P D Wadhwa, O M Wolkowitz, E Puterman,
J Lin, E S Epel. Stress and telomere biology: a lifespan
perspective. Psychoneuroendocrinology. 2013 Sep;38(9):
J H Ford. Saturated fatty acid metabolism is key link between cell
division, cancer, and senescence in cellular and whole
organism aging. Age (Dordr). 2010 Jun;32(2):231-7.
Y Song, N-C Y You, Y Song, M K Kang, L Hou, R Wallace, C B
Eaton, L F Tinker, S Liu. Intake of small-to-medium-chain
saturated fatty acids is associated with peripheral leukocyte
telomere length in postmenopausal women. J Nutr. 2013
J A Nettleton, A Diez-Roux, N S Jenny, A L Fitzpatrick, D R Jacobs
Jr. Dietary patterns, food groups, and telomere length in the
multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr.
T E Strandberg, O Saijonmaa, F Fyhrquist, R S Tilvis, A Y
Strandberg, T A Miettinen, K H Pitkala, V Salomaa. Telomere
length in old age and cholesterol across the life course. J Am
Geriatr Soc. 2011 Oct;59(10):1979-81.
B G P Macnamara, K T Farn, A K Mitra, J K Lloyd, A S Forsbrooke.
Progeria Case Report with Long-term Studies o f Serum Lipids.
Arch Dis Child. 1970 Aug;45(242):553-60.
V A Diaz, A G Mainous III, C J Everett, U J Schoepf, V Codd, N J
Samanii. Effect of healthy lifestyle behaviors on the
association between leukocyte telomere length and coronary
artery calcium. Am J Cardiol. 2010 Sep 1;106(5):659-63.
M A Shammas. Telomeres, lifestyle, cancer, and aging. Curr Opin
Clin Nutr Metab Care. 2011 Jan;14(1):28-34.
I Shalev. Early life stress and telomere length: investigating the
connection and possible mechanisms. Bioessays. 2012
Sanjay Gupta interviews 100-year-old physician, Ellsworth Wareham. Ellsworth credits much of his health and longevity to a plant-based diet.
Healthy Tips and Recipes for Institutions from The Vegetarian Resource Group
Accommodating Vegans in Assisted-Living Facilities
By Chef Nancy Berkoff, RD, EdD
As the population over 50 increases, we will see more and more assisted-living operations. Of course, these facilities will have to meet their clients’ various dietary needs and desires. This is where it can get difficult for the food service operator. It’s relatively easy to prepare 200 vegetarian entrées or 50 non-vegan desserts. It gets more complicated when you’re trying to please a mixed audience with limited cooking staff or cooking space.
MORE INFORMATION AND RECIPES:
Eating More Meat, Dairy, and Other Unhealthful Foods Leads to Worse Aging
April 17, 2013
After an average 16-year follow-up, people who consumed a “Western-type” diet, including a high intake of red and processed meats, whole dairy products, and fried foods, were more likely to die prematurely and to suffer from various chronic diseases including heart disease, stroke, cancer, and mental health disorders, compared with people who avoided such dietary patterns. Researchers analyzed data from 5,350 participants and scored dietary patterns using the Alternative Healthy Eating Index (AHEI) to assess disease risk. People with better AHEI scores had better overall health outcomes as they aged.
Akbaraly T, Sabia S, Hagger-Johnson G, et al. (2013). Does overall diet in midlife predict future aging in phenotypes?
A cohort study. American Journal of Medicine.
2013; 126: pp. 411-419.
How to Slow Brain Aging by Two Years
Telomeres: Cap It All Off With Diet
The consumption of blueberries and strawberries is associated with delayed cognitive aging by as much as 2.5 years, thought to be because of brain-localizing anthocyanin phytonutrients, as shown on functional MRI scans.
J. A. Joseph, B. Shukitt-Hale, N. A. Denisova, D. Bielinski, A. Martin, J.
J. McEwen, P. C. Bickford. Reversals of age-related declines in
neuronal signal transduction, cognitive, and motor behavioral
deficits with blueberry, spinach, or strawberry dietary
supplementation. J. Neurosci. 1999 19(18):8114 - 8121.
R. Krikorian, T. A. Nash, M. D. Shidler, B. Shukitt-Hale, J. A. Joseph.
Concord grape juice supplementation improves memory function in
older adults with mild cognitive impairment. Br. J. Nutr. 2010
103(5):730 - 734.
E. P. Cherniack. A berry thought-provoking idea: The potential role of
plant polyphenols in the treatment of age-related cognitive
disorders. Br. J. Nutr. 2012 108(5):794 - 800.
B. Shukitt-Hale. Blueberries and neuronal aging. Gerontology 2012 58(6):
pp.518 - 523.
E. E. Devore, J. H. Kang, M. M. B. Breteler, F. Grodstein. Dietary intakes
of berries and flavonoids in relation to cognitive decline. Ann.
Neurol. 2012 72(1):135 - 143.
S. M. Poulose, A. N. Carey, B. Shukitt-Hale. Improving brain signaling in
aging: Could berries be the answer? Expert Rev Neurother 2012
12(8):887 - 889.
E. P. Cherniack. A plant-tastic treatment for cognitive disorders.
Maturitas 2012 72(4):265 - 266.
R. Krikorian, E. L. Boespflug, D. E. Fleck, A. L. Stein, J. D. Wightman, M.
D. Shidler, S. Sadat-Hossieny. Concord Grape Juice Supplementation
and Neurocognitive Function in Human Aging. J. Agric. Food. Chem.
R. Krikorian, M. D. Shidler, T. A. Nash, W. Kalt, M. R. Vinqvist-Tymchuk,
B. Shukitt-Hale, J. A. Joseph. Blueberry supplementation improves
memory in older adults. J. Agric. Food. Chem. 2010 58(7):
3996 - 4000.
Schaffer S1, Eckert GP, Schmitt-Schillig S, Müller WE. Plant foods and
brain aging: a critical appraisal. Forum Nutr. 2006;59:86-115.
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